Supranuclear Palsy, Progressive

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Supranuclear Palsy, Progressive

Synonym(s) - Ophthalmoplegia, Progressive Supranuclear - Progressive Supranuclear Ophthalmoplegia - Steele-Richardson-Olszewski Syndrome - Palsy, Progressive Supranuclear - Steele-Richardson-Olszewski Disease

Definition: A degenerative disease of the central nervous system characterized by balance difficulties; OCULAR MOTILITY DISORDERS (supranuclear ophthalmoplegia); DYSARTHRIA; swallowing difficulties; and axial DYSTONIA. Onset is usually in the fifth decade and disease progression occurs over several years. Pathologic findings include neurofibrillary degeneration and neuronal loss in the dorsal MESENCEPHALON; SUBTHALAMIC NUCLEUS; RED NUCLEUS; pallidum; dentate nucleus; and vestibular nuclei. (From Adams et al., Principles of Neurology, 6th ed, pp1076-7)

Broader term(s)

 

MeSH © U.S. National Library of Medicine®.

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